Efficient Chemistry and effective Physics for the development of drugs for Rare Diseases

Tecno Saber 3000 C.A. is a company dedicated to the research and development of technological products in the field of renewable energies, the chemical industry, biomedicine and the development of proposals and prototypes to improve science education. 

Tecno Sabre 3000 CA's purpose is to provide our customers with solutions through the integration of high level technological products, expanding our offer all over the world, based on the creation of high prestige technologies and an organizational structure based on discipline, organization, work and intelligence for the approach of the required solutions.

Our Values

- Love for Education 
- Commitment to
- Ethic
- Client Orientation
- Adaptability to Change
- Integrity
- Innovation
- Professionalism

In Tecno Sabre 3000 CA we strive to become the most attractive technological company for professionals, public and private institutions that want to transform society and the technological partner of companies that need to incorporate technologies to improve and optimize their business in a competitive and industrial way as well as in sustainable and harmonious organizational growth with the environment. 

Our educational products for the teaching of science; has the intention to innovate in the production of educational technologies that tend to have a direct impact on school efficiency and the quality of education in each country. The didactic games produced are designed as tools to help teachers, as a complement to their pedagogy and to considerably increase the resources of access and presentation of content to students with innovative tools for access to information and knowledge.

See link : https://youtu.be/1LkntBrSF-g

Our Physical and Theoretical Research Models supported by computer technologies, robotics, artificial intelligence, supervised learning and solid knowledge in the area of science, are validated in our country by the highest authorities in education, science and technology.   Among many models we have a physical model validated by the National Center for the Improvement of Scientific Education CENAMEC of the Bolivarian Republic of Venezuela, called: Simulator of Atoms and Molecules (SAM 3D).

See link : https://youtu.be/o3y68DEz6P8

Due to the transcendence of the Simulator of Atoms and Molecules (SAM 3D) in the research area, in 2014 the president of the company Technologist Olinto Rosales was accredited as Class A Innovator by the program of stimulus to research and innovation PEII-2014 by the People's Ministry for University Education, Science and Technology of Venezuela. 

From a technological point of view, among other advances, we can guarantee that we already have a prototype of artificial intelligence software called "MICROBIOTIC SOFTWARE AI"; a prototype of Artificial Intelligence software with algorithms trained in the analysis and recognition of images; through the observation of samples processed with scanning electron microscopes obtained from data from open sources such as the Human Microbiome project or from private laboratories interested in our initiative. These algorithms are trained to analyze, detect and classify gut microbiota bacteria based on characteristics such as size, morphology and cluster types. 

This software is in the advanced stage of supervised training and with favorable prognosis based on recent tests indicating that very soon it will be mature enough to face the immense task of analyzing, selecting and classifying with a high degree of accuracy bacteria taken from real tests.  

According to the World Health Organization (WHO), there are about 7,000 rare diseases affecting 7% of the world's population. There are about 7,000 rare diseases in the world with different symptoms and disorders, even within the same disease. Most of them are chronic, degenerative and non-contagious. 65% of these diseases are severe and disabling and affect mental abilities, physical capacities and sensory and behavioral qualities, even leading to single or multiple handicaps and chronic pain. Almost all these pathologies appear in the pediatric age, due to their genetic origin and congenital anomalies. That is to say, they usually have an early onset, appearing around the age of 2 years. On the other hand, many patients present chronic pain and development of motor or intellectual deficit, which makes them lose their autonomy. 

Rare diseases are usually attributed 35% of deaths occurring before the age of one year and 12% in people between 5 and 15 years of age. The average time to reach a proper diagnosis is about 5 years. In case of suspicion of a rare disease, it is advisable to perform a genetic test. Knowing if there is a genetic cause allows to know the evolution of the pathology and to anticipate the symptoms. However, in many cases, a confirmed diagnosis can be very difficult to obtain. The average time is about 5 years and, in some patients, it can take 10 years before they are diagnosed with a rare disease. The exact causes of these diseases are not known, although it is estimated that 80% of them are genetic in origin.

Orphan drugs are those that are used to treat these diseases. However, it should be noted that they are only effective in 10-15% of rare diseases, and never to cure them, but to control them or delay their onset. The problem is that the process from the time a new molecule is discovered until it is marketed is very long, unsafe and requires a very high investment, so that in general the capital invested in its research cannot be recovered and neither does it guarantee an effective treatment.

Due to the genetic origin of rare diseases, they also involve a great deal of effort and contribution pharmacogenomics, which is the study of how genes affect a person's response to drugs. This field combines pharmacology (the study of drugs) and genomics (the study of genes and their functions) to develop safe drugs that can be prescribed based on each person's genetic makeup. Many drugs that are currently available are "one size fits all," but they do not work the same for everyone. It can be difficult to predict who will benefit from a drug, who will not respond, and who will experience negative side effects (called adverse reactions). Researchers are now learning how variants in genes affect the body's response to drugs. 

In our solution we work with new drug manufacturing technologies capable of overcoming all the difficulties mentioned above. 

In the 70's of the last century astronomers with the help of modern and powerful telescopes, evidenced the existence of two hitherto unknown elements of the universe, one was the so-called dark matter and the other the so-called dark energy. On March 21, 2013, the new results of the work carried out by the Plancks satellite on the distribution of the background radiation of the universe throughout the sky were released, and a more precise estimate of 68.3% dark energy, 26.8% dark matter and 4.9% ordinary matter was obtained.

The company Tecno Saber 3000 CA; in the last 25 years has developed a wide range of physical and theoretical models that offer the possibility of creating a proven Physical Theory; which allows to study the behavior of Dark Matter and Dark Energy energy to take advantage of its use for the benefit of humanity; our theory is called "Vacuum Energy Gravitation Theory".

This new knowledge has generated new equations, models and essential concepts to apply and develop a technology that has allowed us to calculate and measure: 

1.-The amount of Dark Matter and Dark Energy distributed around each of the elements of the periodic table.  

2.-The amount of Dark Matter and Dark Energy distributed around molecules essential for life (water, methane, amino acids, sugars and peptides).

3.-The amount of Dark Matter in a mixture or solution as a function of Avogadro's number for any chemical reaction. 

4.- The amount of Dark Energy of a mixture or solution as a function of Avogadro's number and Boltzmann's constant for any chemical reaction. 

5.- How the amount of Dark Matter and Dark Energy influence the factors that affect the rate of a chemical reaction: the concentration of the reactants, the degree of partitioning, the temperature, the existence of catalysts.

6.- How the amount of Dark Matter and Dark Energy facilitate or hinder the creation, modification and separation of an organic or inorganic molecule. 

The aforementioned knowledge has allowed us to develop a prototype technology that allows us to build the chemical structure of any chemical substance based on the information about the way in which the different atoms or ions that make up the molecule, or atomic aggregate, are linked. 

The use of this technology allows the conformation, design and manufacture of new molecules with the same ease and diversity with which Mother Nature works in record times. This technology allows us to produce and implement more appropriate and specific gene therapies for each type of rare disease, as well as providing us with the most advanced technique to develop more effective drugs with fewer adverse effects.

This technology facilitates the genetic engineering necessary to repair and manufacture complex structures such as chromosomes; correcting their structural flaws associated with rare diseases; so that it is expressed correctly in the next cell division through regenerative medicine techniques; with stem cells from the patient; but cloned with the same chromosome structure fully repaired (to prevent immune rejection).

When considering the total number of people worldwide who have a rare disease, around 350 million, the main characteristic of this type of diseases (their low frequency when each rare disease is considered separately) is diluted in the face of the great weight they represent for society and healthcare (Its worldwide impact according to the global genes project is greater than that of cancer and AIDS combined).  Due to the low prevalence of rare diseases compared to the majority; it is estimated that they affect only about 6% of the world's population. It is estimated that about 80 % of these diseases are genetic, 50 % affect children and 30 % die before the age of five. Although pharmacotherapy exists to treat these conditions, the development and production of any drug is an expensive process and, because the pharmaceutical industry aspires to be the most profitable business, these drugs, known as orphan drugs, are in low demand, are very expensive and sometimes discontinued.

Of the more than 7000 rare diseases described, very few, barely 5%, have effective treatments, which represents a major shortcoming for many patients. In this context, basic and applied research, aimed at gaining a better understanding of disease mechanisms and identifying new therapeutic avenues, become essential allies in improving the health or care of patients. The Food and Drug Administration (FDA) defines rare diseases as those that affect fewer than 200,000 people in the United States of America (USA), while the European Union considers a disease to be rare when it affects 1 in 2,000 people. Likewise, the rarity of diseases also depends on the geographical area; for example, in the USA, tuberculosis is considered a rare disease even though it is one of the ten leading causes of death worldwide. However, regardless of the definition, it is clear that these are conditions that, due to their low frequency, are not a priority for health systems and, because little is known about them, their diagnosis and treatment are difficult and costly.

Thus, the development of a treatment for a rare disease begins in a laboratory, continues with orphan drug designation, progresses from preclinical studies and clinical trials to approval by a regulatory agency, and ends with the patient. This development has numerous bottlenecks, some of the most prominent being the fact that many rare diseases are poorly understood or under-researched, the difficulties associated with developing targeted treatments for few patients, and a general limitation to all drug development, which is that only a few candidates show sufficient safety and efficacy to ultimately be used in humans.

Given the genetic origin of most of these diseases, these treatments are often aimed at restoring lost function or restoring a gain of abnormal function caused by a genetic alteration.

As the recent emergence of genome editing tools adds a new dimension to the therapeutic landscape, our prototype technology is being targeted and developed to realize the possibility of a permanent cure for all rare diseases.

                                            Physical Model 

To develop our calculations and theoretical models we have a physical model validated by the National Center for the Improvement of Scientific Education CENAMEC of the Bolivarian Republic of Venezuela, called: Simulator of Atoms and Molecules (SAM 3D). After being evaluated and validated by the Ministry of Education of Venezuela with the help of CENAMEC (National Center for the Improvement of Science Education), an entity attached to the Ministry and authorized to issue its validation, it was determined that SAM 3D provides a number of benefits for the area of research and teaching, among which we can mention: 

1. It increases the level of attention, perception, reasoning capacity, creativity and memory of the users.

2. It develops in a more complete and enjoyable way all the scientific subjects taught in the classrooms of schools, colleges and universities.

3. Increases the productivity and efficiency of the teaching and research process.

4. Increases effectiveness with respect to learning results.

5. Reduces the level of abstraction of science.

6. It represents a great solution for teaching and research in quantum mechanics.

7. It makes learning more permanent.

8. It takes advantage of emotional states and senses.

9. Maximizes the potential of the study and research environment.

10. It is a product made with export quality that would have as clients and beneficiaries the main educational centers and universities in the world.

11. It reduces the average time of permanence to finish a career or research project.

12. It allows students to pass more easily.

13. Provides the opportunity to efficiently acquire applicable knowledge and skills.

14. It uses methodologies that increase the active participation of students and researchers.

15. Reduces the effort of preparation of the subject.

16. Decreases the attrition rate.

17. It improves the intrinsic motivation of the student and the researcher.

18. It represents an intentional change that is made for the purpose of improvement. 

19. Its massive application in any educational system can contribute significantly to the formation of a greater number of future scientists in the world, thanks to the fact that it stimulates new generations to study and love science.

The Simulator of Atoms and Molecules 3D (SAM3D) is a state-of-the-art educational and research tool, capable of providing an experiential foray into the world of atoms, simulating their three-dimensional shape and how they come together to form molecules.

The operation of this invention is based on a 1.64-meter-high sculpture covered with LED bulbs that light up according to the orders of a computer with the help of electronic circuits that serve as an interface. In addition, SAM3D has an accessory called a mirror maze that was designed with the intention of recreating optical illusions.

The software of this invention consists of a kind of virtual periodic table; where you can click on buttons identified with internationally known chemical symbols of the atom or molecule to be simulated. The SAM 3D simulator should be turned on in a preferably dark classroom. 

Usually when we present SAM 3D in schools, congresses or universities due to time and space issues; we set up an exhibition stand with air conditioning, microphones and Video Beam that serves as a traveling classroom.

The great solution that SAM 3D brings to the process of teaching and research in the natural sciences is to overcome the great difficulties involved in teaching and generating new knowledge in chemistry and physics. When it comes to studying matter and its behavior, we often encounter methodological problems and conceptual difficulties that prevent its optimal understanding. The microscopic point of view of matter takes into account the atomic structure, that is, its discontinuous, granular character, with spaces between and within the atoms, formed by an enormous amount of particles separated from each other and in continuous movement. The theory that best explains these phenomena is the Quantum Mechanics of the physicist Erwin Schrödinger 1926, which shows what can be calculated for an electron: its energy level and the probability of finding it within a particular region of space around the nucleus, known as an "orbital".

SAM 3D explains the most difficult concepts of quantum mechanics obtaining the most incredible and unsurpassed educational results; with the most expeditious and beautiful methodology that involves recreating with three-dimensional realism. This 3D experience helps students and researchers to interact for example with the shape of the oxygen atom, touch it and walk around it, appreciating its structure brought to a scale comparable to the size of a person. Likewise, thanks to the mirror maze, it offers the opportunity to witness the formation of giant molecules in the form of methane gas, water or macromolecules. As never before, this bold and pioneering recreation is done while respecting and materializing scientific laws such as Pauli's exclusion principle, Hund's rule, Aufbau's principle or the laws of chemical bonding. This educational environment can considerably increase the level of attention, perception, reasoning ability, creativity and memory of students and researchers using an essentially analog model and contributes to making science more relevant and interesting.

The ingenious SAM 3D represents, according to its application, a technologically different and improved innovation; since, in a magical and surprising way, after lighting up in the dark, atoms such as hydrogen (H), fluorine (F) or carbon (C) and molecules such as ammonia (NH3) and water (H2O), among others, begin to float in the air; in a very reliable way to the postulates of quantum mechanics, implying a version very close to reality. In this order of ideas SAM 3D manages to represent the electronic configuration of the atoms that constitute the first two periods of the "Periodic Table", from Hydrogen (Z=1) to Neon (Z=10), as well as complex geometries such as tetrahedral, pyramidal, octahedral, etc., which imply the formation of molecules.

The versatility of the 3D design of the SAM allows the simulation of molecular phenomena according to the electron pair repulsion theory (an additional classical molecular model, but of great scientific utility). This second theoretical tool exemplifies electrostatic repulsion and how electron pairs in valence orbitals can be arranged around the atom to be as far apart as possible to generate a highly stable molecular geometry. By applying this classical theory, it is possible to simulate the geometry of more than 60 types of molecules with the same structure.

Throughout the years the Atom and Molecule Simulator (3D SAM) has received different awards and recognitions among which are:

2013 Silver Medal and Second Place of Honor" as second most outstanding work for the project: "3D Atom and Molecule Simulator"; in the Science, Technology and Innovation Award "Dr. Humberto Fernández-Morán" of the Municipality Libertador-Caracas.

2013 Finalist in the International award "Science in Action" in Madrid-Spain with the project: "3D Atom and Molecule Simulator".

2012 Finalist in the International award "Ciencia en Acción" in Madrid-Spain with the project: "Simulador de átomos y Moléculas 3D".

2012 Winner of Gold Medal and First Place of Honor, as the most outstanding work of the project: "Atomic World"; in the Science, Technology and Innovation Award "Dr. Humberto Fernández-Morán" of the Municipality Libertador-Caracas.

2011 Silver Medal and Second Place of Honor" as second most outstanding work of the project: "Petroquímica Educativa de Venezuela" (PEV); in the Science, Technology and Innovation Award "Dr. Humberto Fernández-Morán" of the Municipality Libertador-Caracas.

2007 Nominated for the FUNDACITE ARAGUA award "Honor to the technological merit of the state of Aragua, mention in education" by the permanent commission of education, culture, sports and youth of the Legislative Council of the state of Aragua.

In the year 2002 during the participation in the I Iberoamerican Congress of students of Chemical Engineering and related careers..., at the Universidad de los Andes, Cultural Center "Tulio Febres Cordero", Merida, Merida State. DOCTOR. H. Scott Fogler of the Department of Chemical Engineering of the University of Michigan-USA, had the opportunity to witness the operation of the Simulator of Atoms and Molecules (SAM 3D); recognizing it as a "fantastic work" leaving his testimony in writing. DOCTOR. H. Scott Fogler has more than 200 publications in the area of petroleum research and has received more than 4 million dollars from government agencies and private companies for research in his laboratory.

If you would like to learn more about the Simulator for Atoms and Molecules (SAM 3D) you can visit the following links:  https://youtu.be/xtmQwfS-TiA

                                 Validated Theoretical Models  

Tecno Saber 3000 CA; in the last 25 years has developed, demonstrated and validated the scientific theory called "Theory of Quantum Gravitation of the Energy of the Vacuum", and has generated new equations, models and essential concepts to apply and develop this solution. 

The scientific theory developed and called "Theory of Quantum Gravitation of the Energy of the Vacuum", has six Hypotheses that have been experimentally proven: 

1.- The space that we know as vacuum behaves as a fluid constituted by dark energy and dark matter which we will call biphasic fluid.

2.- The density of the biphasic fluid varies with temperature (inversely proportional relationship).

3.-Light travels through the two-phase fluid as a density wave in a liquid and its velocity depends on the modulus of elasticity of the fluid volume (expressed in N/m2) and the density of the two-phase fluid.

4.- The speed of light traveling through the two-phase fluid increases as the temperature of the two-phase fluid increases, being able to reach values higher than those currently reported (3𝑥〖10〗^8 𝑚⁄(𝑠 )), so the speed of light is neither a limit of nature nor a universal constant. 

5.- The energy of light traveling through the two-phase fluid increases as the temperature of the fluid increases and that this is only proportional to the frequency for a defined temperature value.

6.- The energy of light traveling in a two-phase fluid (whose temperature increases progressively) depends on the temperature, corresponding to a behavior similar to that defined by Wien's displacement law.

The experiments that the company Tecno Sabre 3000 CA, has carried out for the verification of this theory, are exemplified and explained in the video of the following link:https://youtu.be/vE1psMqE614

 At present; thanks to the equations of the so-called "Quantum Gravitation Theory of the Vacuum Energy", among other achievements; it has been possible to calculate and measure: 

1.-The exact radius of the proton 

2.-The exact radius of the electron

3.-The amount of Dark Matter and Dark Energy distributed around each of the elements of the periodic table.  

4.-The amount of Dark Matter and Dark Energy distributed around molecules essential for life (water, methane, amino acids, sugars and peptides).

5.-The amount of Dark Matter in a mixture or solution as a function of Avogadro's number for any chemical reaction. 

6.- The amount of Dark Energy of a mixture or solution as a function of Avogadro's number and Boltzmann's constant for any chemical reaction. 

7.- How the amount of Dark Matter and Dark Energy influence the factors that affect the rate of a chemical reaction: the concentration of the reactants, the degree of partitioning, the temperature, the existence of catalysts and the contact surface of both the reactants and the catalyst. 

8.- How the amount of Dark Matter and Dark Energy influences the catalysts to increase or decrease the speed of a chemical reaction.

9.- How the amount of Dark Matter and Dark Energy facilitate or hinder the creation, modification and separation of an organic or inorganic molecule. 

10.-The amount of Dark Matter and Dark Energy distributed around each of the planets of the Solar System.

11.-The amount of Dark Matter and Dark Energy distributed around the Sun. 

Although for the purposes of this challenge it is too long to explain our calculations and equations in a simplified way, we can say that taking into account that the vacuum is full of energy (Quantum Energy or Dark Energy) and Dark Matter, in some of our equations the vacuum governs the motion of the particles by the interaction with a two-phase fluid, which for our models generates the pilot waves of Louis de Broglie (Dieppe 1892 - Paris 1987). The physical behavior of these waves can be considered similar to surface waves in a fluid or liquid. The motion of this two-phase fluid dominates the kinematic behavior of each type of particle depending on the value of its associated wavelength. 

The wave motion of this two-phase fluid is analogous to surface waves in a fluid, whether gravity, shallow, or capillary.    

The wave equation at the surface of a liquid is:

Where V is the phase velocity of the fluid, g is the value of gravity on earth, λ is the wavelength of the fluid; T is the surface tension of the fluid, D is the density of the fluid; H is the height of the wave and tgh is the hyperbolic tangent used to calculate the last member of the equation. 

Substituting relations and variables of the motion of a classical fluid from equation 1 by quantum values and concepts associated with our theoretical models; the general equation 1 becomes: 

Where g_ois the value of quantum gravity for a value of density of the two-phase fluid proposed in our theory; ħ is the reduced Planck's constant, m is the mass of the particle moving in the two-phase fluid, v is the value of the velocity of the particle moving in the two-phase fluid, G is the universal gravitational constant; T is the surface tension of the two-phase fluid, H is the height of the energy wave originating in the two-phase fluid and tgh is the hyperbolic tangent used to calculate the last member of the equation.

It is important to keep in mind that equations 2 are only some of the more than 6000 equations and models developed in our company whose interpretation is associated with ideas, discoveries and deep concepts about the functioning of the Universe not yet published or disclosed, so their understanding is not immediate for those who are not familiar with them and their meanings; they are placed in a physical and mathematical context essentially distant from what can be related and understood based on the knowledge provided by the traditional scientific literature and specialized in the subject.

Equation 2, wisely used and applied, allows us to reach physical, chemical and mathematical relationships and conclusions with a high degree of accuracy, from which we can develop a technology that facilitates the creation of any molecule or macromolecule, taking into account the influence of Dark Matter and Dark Energy in the atomic interaction and the generation of chemical bonds, allowing its mass production. This technology is currently in prototype phase and its operation will be explained below. 

           Dark Energy and Dark Matter Chemical Reactor Prototype  

In physics, vacuum is the total absence of matter or energy in a given space or place, or the lack of contents inside a container. In cosmology, baryonic matter is the matter that forms everything that surrounds us and that we can see, including ourselves. For our models, although the vacuum does not possess any type of baryonic matter or any type of energy so far known, it does possess Dark Matter AND Dark energy as explained below. 

In ordinary quantum mechanics, the energy of the Void (Dark Energy); it is the energy associated with the fundamental state of the system. The most famous example of this type is energy: 

Where E is the Vacuum Energy (Dark Energy), ħ is the reduced Planck's constant and w is the angular frequency of the quantum harmonic oscillator.  In this case E is associated with the fundamental state of the quantum harmonic oscillator. More precisely, the zero point energy or Void energy is the expected value of the Hamiltonian of the system.

In our models Dark Matter; is a corpuscular structure; as such, it could be described as a fundamental particle; which, at room temperature of 25 degrees Celsius occupies the empty space forming a fluid whose physical properties of pressure, density, temperature, thermal conductivity and surface tension; can be measured by the equipment we have developed, the physical behavior of two Dark Matter particles is similar to that of a quantum harmonic oscillator mediated by attractive forces; as will be seen by way of illustration in the following image: 

The Dark Energy in equation (3) arises from heating the vacuum and vibrating the Dark Matter particles; as shown in the following image: 

In quantum field theory, the fabric of space is visualized as being composed of fields, with the field at each point in space-time being a quantized simple harmonic oscillator, interacting with neighboring oscillators. In this case, each has a contribution of: 

From every point in space, resulting in a Dark Energy; technically infinite. The Dark Energy is again the expected value of the Hamiltonian; here, however, the phrase expected value of the vacuum is more commonly used, and the energy is christened vacuum energy (Dark Energy). By way of illustration I could understand according to the following picture:

Relationship between the amount of dark matter and Avogadro's number for any chemical reaction:

To understand the relationship between the amount of Dark Matter and Avogadro's number for any chemical reaction, it is first necessary to understand the behavior of Dark Matter and Baryonic matter (atom and molecules). In a defined volume (a container); the Dark Matter particles reduce their radius as the mass of the Baryonic particle increases and thus become denser; affecting the physical properties of the Dark Matter fluid, as illustrated in the following image: 

The concept of Avogadro's number has its roots in the work of the Italian scientist Amedeo Avogadro, who in 1811 proposed that the volume of a gas (at a given pressure and temperature) is proportional to the number of atoms or molecules of the gas, regardless of its chemical nature. Amedeo Avogadro, with his hypothesis that equal volumes of gases contain the same number of molecules, laid the foundations for the constant that bears his name, an essential tool for connecting the macroscopic world with the atomic world. It is easy to intuit from the above image that in the presence of Dark Matter the same number of particles of two different gases will occupy the same volume even though their molecules have different masses and different sizes; by a spatial rearrangement, between the size of the Dark Matter particles and the molecules of the gases occupying both volumes.

Avogadro's number is fundamental to several areas of chemistry and physics:

Moles and molar mass: it allows conversion between the number of particles and the amount of substance in moles. This means that one mole of any substance contains approximately 6.022 x 10^23 particles of that substance. This concept is essential for calculating the amount of reactants and products in a chemical reaction.

Molar volume: relates the volume occupied by one mole of an ideal gas at standard conditions (0°C and 1 atm) to the number of molecules present. This is vital for understanding and predicting the behavior of gases, facilitating calculations in experiments and industrial applications.

Physical constants: connects other fundamental constants such as the gas constant and Boltzmann's constant. These relationships are essential in various equations and theories describing the behavior of matter under different physical and chemical conditions.

In our technology, Avogadro's number is a coefficient that, thanks to changes in temperature, pressure and application of magnetic fields, among other resources to our chemical reagents, relates, directs and quantifies the interaction between Dark Matter and Baryonic Matter (atoms or molecules); allowing us to direct the chemical reactions of the products we wish to obtain from the manipulation of the balance in the interaction of both; facilitating the breaking and formation of bonds at the discretion of our pharmacological designs.

  When you discover something new and understand it, everything is                                                             illuminated...

Innovation is one of the major issues that concerns the pharmaceutical profession because of its intertwining with all sectors and the possibilities for scientific development that it offers. For example, new treatments or optimizing existing ones, increasing competitiveness or improving the quality of life and sustainability of our healthcare systems.The first obstacle in drug development is the science involved in the development of medicine.

Their pharmaceutical and clinical development requires advanced technologies to control all the parameters of the production process. In addition, this type of drug requires that the active ingredients be processed in a closed circuit by highly qualified professionals.  Highly specialized drugs are manufactured in special facilities with state-of-the-art technology and the latest air conditioning, quality and safety systems to ensure that the product has the optimum conditions for handling and maintenance, and that the professionals are fully protected.

The manufacturing process of a drug is divided into seven phases:

1. Weighing.
First, the active ingredients and excipients necessary for the manufacture of a batch of medicines are fractionated and weighed with extreme precision, following in all cases the quantities indicated in the formula of each specialty.

2.-Granulation.
At this stage, the active ingredient and excipients are mixed with a solution to form the wet granules. 

3.-Drying.
During drying, this solution is extracted to obtain a granulate with the appropriate moisture content.

4. Sieving.
The objective of this phase is always to obtain the appropriate granule size for each drug.

5. Mixing.
The necessary excipients are added to the granules for their compression, and then they are mixed until they are perfectly homogeneous. 

6. Compression.
The granules obtained after mixing are pressurized to obtain the tablets.

7. Coating.
In some cases, the tablets are coated with a polymer film, which is applied by means of a spray gun system. This coating forms a barrier between the tablet and the environment. 

Once manufactured, the drugs go to the conditioning process, where they are placed in blister packs to protect them from the environment and are packaged, together with the package leaflet, in their corresponding case.

Our technology works directly with the formation of bonds and chemical substances from the creation of the active ingredients to the coating and conditioning; without differentiating and applying the stages of the manufacturing process (weighing, granulation, drying, mixing, compression) of the drug; because our technology obtains the essential constituents for the manufacture of the active ingredient of the drug (as well as its necessary excipients) from the union of individual atoms without the intervention of complex chemical reactions; That is to say, it is based on an atom by atom placement to form the molecules of the drug and culminates in the coating and conditioning phase; without the excess of advanced technologies to control all the parameters of the production process, thus reducing the costs and the number of personnel required; guaranteeing in turn a higher quality and purity in the manufacturing process. 

Our company Tecno Saber 3000 C A; wishes to continue with this research February 2025 will be able to count on a financing of 500 million dollars to conclude the technology of the prototype and patent it.

During the month of May 2025, our company will create a fund of 300 million dollars called "Heal and Live" Fund; to start with the development and design of drugs and medicines to cure rare diseases, as well as; the design of gene therapies and regenerative medicine techniques with stem cells from the technologies identified and presented in this challenge. 

The intention of our company to present ourselves to the award is for the creation of a multidisciplinary work team between MIT personnel, Amgen and our company, so that supported by a cooperation agreement and financed by the economic resources of the "Healing and Living" Fund, they can organize themselves to develop all the medicines and medical innovations to cure rare diseases.  

Finally, through the formation of a pharmaceutical consortium created by our company; Tecno Saber 3000 C A; is committed to defray the production costs of the drugs developed from the "Heal and Live" fund; and to guarantee their free distribution to patients with rare diseases. 

Our company is the only company in the world; that has developed a diverse range of models (physical and theoretical) and technological applications; able to offer all the competitive advantages to be the only one that can develop, patent and manufacture the technology exposed and explained in this solution; no one knows as much about the functioning of Dark Matter and Dark Energy as we do; let alone, can visualize all the potential uses and applications in the medical, pharmaceutical or energy industry on the planet.