Bionavi Neuronavigation System

Systemed SAS is a Colombian company that provides rental, sales of supplies and equipment for neurosurgery. It has been the main source of income and development for Bionavi.

Thousands of people die every year in Latin America and emerging economies due to lack of access to technologies such as neuronavigation in both public and private healthcare institutions. This leads to more invasive surgeries for patients, higher risk of complications during surgery, longer hospital stays, higher medical costs, and even increased mortality risk.

More than 600 million people in Latin America do not have access to this technology, limiting access to quality medical care. A global study published in the journal Neurosurgery found that the mortality rate in brain tumor surgeries was 12% higher in emerging economies compared to developed countries due to the limited access of patients to treatment with the aid of neuronavigation. A similar study in Brazil found that the rate of surgical site infections in brain surgery was 18% higher in hospitals that did not have access to neuronavigation.

The lack of access to neuronavigation is a serious public health problem that can lead to deaths and serious complications. It is necessary to increase access to this technology worldwide, especially in emerging economies.

It is important to note that neuronavigation is a valuable tool that can help surgeons perform more precise and safer procedures, however, it should only be used by healthcare professionals in Neurosurgery, Otorhinolaryngology, and Orthopedics with adequate training for its correct use.

Low-cost Neuronavigation Prototype for Latin America and Emerging Economies

What is it?
It is an image-guided surgery system used by specialist doctors in neurosurgical interventions to observe and precisely locate lesions, as well as different elements of the anatomy of any patient. The system is designed to be easy to use, with functionalities and precision comparable to equipment available in the market, but unlike these, it is affordable for clinics and hospitals in emerging economies.

What does it do?
The low-cost neuronavigation prototype allows surgeons to:
- Visualize the patient's anatomy in 3D with high precision.
- View the patient's anatomy in three planes: Axial, Transversal, and Longitudinal.
- Plan and execute surgical procedures with greater precision.
- Provide information on the location of lesions and surgical instruments with calculated precision errors of less than 0.5mm.
- Enable less invasive surgeries by using this technology, reducing the need for extensive incisions or invasive interventions.
- Reduce the risk of complications during surgery, such as surgical site infections, bleeding, and neurological injuries.
- Generate benefits for patients, such as faster recovery times, less postoperative pain, and a lower probability of complications.
- Reduce medical costs.

How does it work?
The low-cost neuronavigation prototype works as follows:
1. Image acquisition: A computed tomography (CT) or magnetic resonance imaging (MRI) scan of the patient's brain is taken.
2. Image segmentation: The images are processed to identify and segment the relevant anatomy of the patient's brain.
3. Image registration: The segmented images are registered with the patient in the operating room.
4. Instrument calibration: When a procedure is initiated, the instruments to be used are calibrated through a process of repeated measurements at different locations on the patient's head, ensuring the correct acquisition of instrument parameters and dimensions with respect to the patient's position.
5. Surgical navigation: The surgeon uses a pointer or any previously calibrated instrument to navigate through the patient's anatomy in real-time.
6. Visualization: The patient's anatomy and the position of the different instruments are displayed on a screen in the operating room with great precision.

Technology used:
The low-cost neuronavigation prototype uses the following technologies:
- Image processing software: To segment and register medical images.
- Tracking hardware: Consists of an infrared tracking camera that uses optical technology to accurately track the position and orientation of medical instruments and devices in real-time within the surgical field.
- Display screen: To show the patient's anatomy and the position of the probe.
- Medical-grade cart: A cart with suitable supports for both the computing system and the tracking camera is used to integrate the equipment as a compact unit, which, thanks to its wheels, allows for practical movement of the equipment around the operating room.
- UPS (Uninterruptible Power Supply): Optionally, a UPS system can be installed to allow continuous use of the equipment for a specified time in the event of electrical power failure.

Whom Does Our Solution Serve and How Will It Impact Their Lives?

Target Population:
Our solution, the low-cost neuronavigation prototype for Latin America, is primarily aimed at the following population groups in developing countries:
- Patients requiring treatments or procedures in neurosurgery: These patients may include individuals with brain tumors, brain aneurysms, traumatic brain injuries, and other neurological conditions requiring surgical intervention.
- Neurosurgeons: These medical professionals are responsible for performing complex surgeries on the brain and spine.
- Hospitals in emerging economies: These hospitals often lack the resources to acquire expensive commercial neuronavigation systems, limiting patients' access to this vital technology.

Current Needs:
Currently, patients with neural injuries or diseases in developing countries often face the following challenges:
- Limited access to neuronavigation: The lack of access to neuronavigation systems can increase the risk of complications during surgery, such as surgical site infections, bleeding, and neurological injuries.
- Invasive and less precise surgeries: Without neuronavigation, surgeons may struggle to visualize the patient's anatomy accurately, leading to longer and more complex invasive procedures.
- Higher mortality rates: Lack of access to neuronavigation can contribute to higher mortality rates in patients undergoing neurosurgery.

How Our Solution Will Address These Needs:
Our low-cost neuronavigation prototype has the potential to address the needs of this target population in the following ways:
- Cost reduction of neuronavigation: By being more affordable, our system can increase access to this technology for hospitals in developing countries.
- Improved surgery precision: Neuronavigation can assist surgeons in performing more precise and safer procedures, which can reduce the risk of complications and improve outcomes for patients and their quality of life.
- Decreased mortality rates: By improving surgery precision and reducing the risk of complications, our system can contribute to decreasing mortality rates in patients undergoing neurosurgery.

Conclusion:
Our low-cost neuronavigation prototype has the potential to be a valuable tool in improving the quality of neurosurgical healthcare in developing countries. By increasing access to this technology, we can help improve outcomes for patients and save lives!

How Are We Well-Positioned to Offer This Solution?

Team Experience and Skills:
The initiative to develop a more affordable neuronavigation system stems from Dr. José A. Name Guerra's medical practice experience. Returning from his specialization in Neurosurgery in Germany, he observed limited access to neuronavigation technology among neurosurgeons in Colombia, which is essential for precise surgical interventions. Dr. Name, lacking these tools, formed an interdisciplinary team of healthcare professionals and engineers to design and develop a functional, low-cost neuronavigation system tailored to the needs of cranial navigation.

During the development phase, our team conducted interviews with Colombian neurosurgeons to better understand their needs and the limitations of existing commercial systems. This valuable feedback guided the design of our prototype.

Our team comprises highly qualified professionals:
- Dr. José Antonio Name Guerra: Experienced neurosurgeon with insight into the needs of surgeons and patients.
- Eng. Armando Portela Duarte: Electronics engineer skilled in product design, software development, and medical equipment maintenance.
- Eng. Jairo Alonzo Pérez Leal: Mechanical engineer experienced in design and ergonomics, crucial for instrument development.
- Eng. Julio Cesar Pérez Franco: Systems engineer proficient in software design and medical image processing, ensuring the functionality and usability of our system.

Knowledge of the Local Context:
Dr. Name Guerra's firsthand experience with the challenges faced by Colombian neurosurgeons and patients informed our solution's design. Our engineering team's extensive experience in medical equipment maintenance further ensures its suitability for local settings.

Community Collaboration:
We are committed to community engagement to uphold the highest standards for our solution:
- Through the ethics committee of the University of Norte in Barranquilla, Colombia, we conducted clinical trials on low-income neuro patients. Feedback from patients and specialists has been instrumental in refining our prototype.
- Our partnership with Porto Azul Clinic in Barranquilla, Colombia, enables frequent use of our Bionavi system by specialists. Detailed records of surgeries performed help identify areas for improvement.

In Conclusion:
Our team is well-equipped to offer the low-cost neuronavigation prototype to developing countries' populations. With our experience, skills, and commitment, we aim to address the pressing need for affordable neurosurgical technology, ultimately improving healthcare outcomes in underserved communities.

What Have We Built and Tested So Far?
We have designed and developed several versions of prototypes and their corresponding accessories and instruments, implementing a continuous improvement process until achieving a functional prototype of the neuronavigation system. The prototype has been tested in a laboratory environment and has proven to be accurate and reliable. Once we ensured functionality, stability, and precision of the system as a whole, over 1000 tests were conducted in clinical interventions. Initially, paired tests were conducted with commercial equipment to comparatively record the behavior and precision of our equipment with respect to that of commercial equipment.

How Many Clients or Beneficiaries Have We Served?
Once we ensured the ability to offer a reliable product to the market, we began an early stage of marketing activities for the equipment in our country, Colombia, where we obtained the required permits from the health authorities. We have already sold and installed 4 units in different clinics and hospitals in cities such as Barranquilla, Villavicencio, Popayán, and Cúcuta.

Why Did We Choose the "Growth" Stage?
We selected the "Growth" stage for the following reasons:
- We have developed a functional prototype that has been tested in a laboratory environment and undergone successful clinical trials.
- We have received positive feedback from numerous specialists in Neurosurgery, Orthopedics, Otorhinolaryngology, and hospital administrators at various medical congresses and fairs in Colombia and countries such as the United States, Turkey, and the United Arab Emirates.
- We have an experienced team with the skills and expertise necessary to bring the product to market.
- We have identified a large and receptive market for our solution in Latin America and developing countries.
- We have secured funding for the entire development project up to this point, but we require additional resources to achieve our marketing and growth objectives.

Future Plans:
In the future, we plan to:
- Address the existing demand in our country, Colombia.
- Establish a company to manufacture and market the system internationally.
- Obtain international regulatory approval (FDA, CE).
- Expand our presence to other countries in Latin America and around the world.
We believe that our solution has the potential to significantly improve the lives of people in Latin America by providing them with access to quality neurosurgical healthcare.

Why Are We Applying to Solve?
We are applying to Solve because we believe that our solution has the potential to address a significant public health problem in Latin America, and Solve can help us overcome the barriers we face in scaling our solution.
Barriers We Face:
- Regulatory Barriers: We cannot offer, market, or bring our equipment to other countries without obtaining FDA and CE registration in Europe. These processes are costly and complex, and without proper collaboration, it may take us several years to complete them.
- Financial Barriers: We lack the financial resources needed to complete the FDA registration process, conduct large-scale clinical trials, and establish a company to manufacture and market the system internationally.
- Knowledge Barriers: There is a lack of awareness about low-cost neuronavigation and its benefits in Latin America. This makes it difficult to create demand for our product.
How Solve Can Help Us:
- Funding: Solve can provide us with the funding needed to complete the FDA registration process, conduct large-scale clinical trials, and establish a company to manufacture and market the system.
- Advisory: Solve can provide us with expert advice on regulatory, financial, and marketing matters.
- Connections: Solve can connect us with potential partners who can help us scale our solution.
Social Impact:
Our solution has the potential to significantly improve the lives of people in Latin America by providing them with access to quality neurosurgical healthcare. By reducing the risk of complications during surgery, improving patient outcomes, and reducing healthcare costs, our solution can save lives and improve the quality of life for thousands of people.
Conclusion:
We believe that Solve is the ideal partner to help us overcome the barriers we face and scale our solution. With Solve's support, we can have a significant positive impact on the lives of people in Latin America.

What Makes Bionavi Innovative? Problem Approach: Bionavi addresses the problem of limited access to neuronavigation in low- and middle-income countries in a new and significantly improved way compared to existing solutions:

1. Price: Bionavi is up to 10 times cheaper than existing commercial systems, making it accessible to a larger number of patients and hospitals.
2. Portability: Bionavi is disassemblable and easy to transport, ideal for remote areas or those with limited infrastructure.
3. Ease of Use: Bionavi features an intuitive interface that allows surgeons of varying experience levels to use it with ease.
4. Adaptability: Bionavi is designed to be compatible with a wide range of medical equipment, increasing its versatility and reducing costs.
5. Ergonomics: Bionavi instruments are designed by neurosurgeons for neurosurgeons, incorporating all the features and requirements that a direct user, such as our scientific director, has outlined based on their experience and feedback from many colleagues.

Positive Impact: Bionavi has the potential to catalyze broader positive impacts in the field of neurosurgical healthcare in Latin America:

• Reduction of Inequalities: By providing access to cutting-edge technology to patients in low- and middle-income countries, Bionavi helps bridge the gap in healthcare and reduces health inequalities.
• Improvement of Care Quality: Bionavi enables surgeons to perform more precise and safer procedures, enhancing patient outcomes and reducing mortality.
• Cost Reduction: Bionavi helps reduce medical costs for patients and hospitals, freeing up resources for other healthcare services.
• Stimulation of Innovation: Bionavi's success could encourage other companies to develop innovative and low-cost medical solutions for developing countries.

Market Change: Bionavi has the potential to change the neuronavigation market in the following ways:

• Market Expansion: By making neuronavigation accessible to a greater number of patients and hospitals, Bionavi would significantly expand the market for this technology.
• Price Reduction: Competition from Bionavi could pressure manufacturers of existing commercial systems to lower their prices, making them more accessible to all.
• Competition Stimulation: Bionavi's success could incentivize other companies to enter the market, increasing competition and innovation.

In summary, Bionavi is an innovative solution with the potential to transform neurosurgical healthcare in Latin America and improve the lives of thousands of people.

Theory of Change: Bionavi
Problem:
Millions of people in low- and middle-income countries (LMICs) around the world lack access to neuronavigation, a crucial technology for precise and safe neurosurgical procedures. This increases the risk of complications, injuries, and even death during surgeries.
Solution:
Bionavi, an innovative, portable, and low-cost neuronavigation system, offers a viable solution to this problem. Specifically designed for the needs of LMICs, Bionavi makes cutting-edge technology accessible to patients who previously did not have it, significantly improving their chances of survival and quality of life.
Impact:
Immediate Outcomes:
• Availability of neuronavigation: Bionavi is implemented in hospitals and health centers in LMICs, increasing access to this crucial technology.
• Safer neurosurgical procedures: Surgeons use Bionavi to perform more precise procedures and minimize the risk of complications.
• Better medical care: Patients benefit from higher-quality neurosurgical care, with improved outcomes and lower mortality.
Long-Term Outcomes:
• Reduction of mortality: More lives are saved thanks to safer neurosurgical procedures.
• Improved quality of life: Patients experience faster recovery and reduced postoperative disability.
• Reduction of medical costs: It reduces the financial burden for patients and healthcare systems.
• Greater health equity: The gap in access to cutting-edge medical technology between developed countries and LMICs is reduced.
Evidence:
• Clinical studies: Bionavi has demonstrated its effectiveness in clinical studies, with results comparable to existing commercial systems.
• Practical experience: 6 Bionavi systems have been successfully implemented in Our country Colombia, improving the quality of medical care and, why not? saving lives!
• Positive feedback: Surgeons, patients, and hospital administrators in LMICs have praised the ease of use, portability, and low cost of Bionavi.
Conclusion:
Bionavi not only saves lives but also transforms neurosurgical healthcare in LMICs. By making cutting-edge neuronavigation accessible, Bionavi promotes health equity, improves quality of life, and contributes to the social and economic development of communities worldwide.

Impact Objectives for Bionavi

Objective 1: Increase access to neuronavigation in low- and middle-income countries (LMICs)
• Progress Measurement:
  - Number of hospitals and health centers in LMICs implementing Bionavi.
  - Percentage of neurosurgical patients in LMICs with access to neuronavigation.
  - Decrease in the number of neurosurgical procedures performed without neuronavigation in LMICs.

Objective 2: Improve safety and outcomes of neurosurgical surgeries in LMICs
• Progress Measurement:
  - Rate of complications during neurosurgical surgeries in LMICs with Bionavi.
  - Mortality rate during neurosurgical surgeries in LMICs with Bionavi.
  - Average duration of neurosurgical surgeries in LMICs with Bionavi.
  - Patient satisfaction with the outcomes of neurosurgical surgeries performed with Bionavi.

Objective 3: Reduce costs of neurosurgical healthcare in LMICs
• Progress Measurement:
  - Average cost of neurosurgical surgeries in LMICs with Bionavi.
  - Savings in medical costs for patients and healthcare systems in LMICs due to Bionavi.
  - Decrease in financial burden for patients and families as a result of neurosurgical surgeries performed with Bionavi.

Objective 4: Promote health equity and social development in LMICs
• Progress Measurement:
  - Reduction of the gap in access to cutting-edge medical technology between developed countries and LMICs.
  - Improvement of the quality of life for neurosurgical patients in LMICs.
  - Contribution to the social and economic development of communities in LMICs through the enhancement of healthcare.

Additional Indicators:
- Number of scientific publications citing Bionavi.
- Number of awards and recognitions received by Bionavi.
- Satisfaction level of Bionavi's partners and collaborators.
- Economic impact of Bionavi on communities in LMICs.

Conclusion:
Bionavi not only saves lives but also transforms neurosurgical healthcare in LMICs. By making cutting-edge neuronavigation accessible, Bionavi promotes health equity, improves quality of life, and contributes to the social and economic development of communities worldwide.

Core Technology of Bionavi

Bionavi relies on a combination of advanced technologies and engineering expertise to provide an innovative, portable, and cost-effective neuronavigation solution:

1. Optical Localization:
- It uses high-resolution cameras to capture images of the patient's anatomy during surgery.
- These images are processed using software algorithms to create an accurate 3D representation of the surgical field.

2. Image Registration:
- It employs image registration techniques to merge the 3D representation of the surgical field with preoperative magnetic resonance imaging or computed tomography images of the patient.
- This allows surgeons to visualize the location of their instruments' tips in relation to the patient's anatomy in real-time.

3. Guided Navigation:
- It provides surgeons with visual guidance during surgery, assisting them in accurately navigating towards the surgical target while avoiding critical structures.
- This improves the accuracy and safety of neurosurgical procedures, reducing the risk of complications.

4. Modular Design:
- Bionavi is designed with modular components that can be easily assembled and disassembled.
- This makes it portable and easy to transport, ideal for use in resource-limited settings or areas with poor infrastructure.

5. Intuitive Software:
- It features an intuitive software interface that is easy to use by surgeons of varying experience levels.
- This reduces the learning curve and allows more surgeons to benefit from neuronavigation technology.

Innovation:
Bionavi distinguishes itself from existing commercial neuronavigation systems in several key aspects:
- Low Cost: Bionavi is up to 10 times cheaper than commercial systems, making it accessible to a larger number of patients and hospitals in low- and middle-income countries.
- Portability: Bionavi is disassemblable and easy to transport, ideal for use in remote areas or with limited infrastructure.
- Ease of Use: Bionavi features an intuitive interface that allows surgeons of different experience levels to use it with ease.
- Adaptability: Bionavi is designed to be compatible with a wide range of medical equipment, increasing its versatility and reducing costs.

Conclusion:
The combination of advanced technologies and engineering expertise in Bionavi makes it an innovative and effective solution for neuronavigation in low- and middle-income countries. Its low cost, portability, ease of use, and adaptability make it ideal for improving neurosurgical healthcare in communities worldwide.

Bionavi Solutions Team:
- Full-time: 6 people
- Part-time: 7 people
- Contractors: 1 people
Total: 14 people

Team Description:
The Bionavi Solutions team comprises medical professionals, engineers,  marketing experts, and business development specialists. We work together to develop, implement, and scale our low-cost neuronavigation solution for low- and middle-income countries.

Bionavi's Work Timeline:
Development of Bionavi began 12 years ago, in 2012. It started slowly in the first few years as a research and basic testing endeavor. By 2014, we successfully developed the first functional prototype, conducting initial tests with anatomical models to assess precision and generating scientific articles detailing our progress and results. Over time, we established a process of continuous improvement based on clinical trial results and user feedback. Through this process, we achieved the development of the current system by implementing enhancements. We obtained marketing permits in Colombia and since we have been working on commercializing the equipment.

Diversity, Equity, and Inclusion at Bionavi

At Bionavi, we are committed to creating a diverse, equitable, and inclusive team where all members feel valued, respected, and have the opportunity to reach their full potential. We believe that diversity of ideas, perspectives, and experiences is essential for innovation and success.

Diversity in Leadership Team:
1. Our leadership team comprises individuals from different backgrounds, cultures, genders, ages, and professional experiences.
2. We strive to represent the diversity of the communities we serve and the perspectives of patients, caregivers, and medical professionals.

Diversity, Equity, and Inclusion Objectives:
1. Increase representation of underrepresented groups in our team: We aim to increase the representation of women, people of color, individuals with disabilities, and members of the LGBTQ+ community in our team.
2. Create an inclusive work environment: We are working to create a work environment where everyone feels safe, valued, and respected.
3. Promote equity in opportunities: We are committed to ensuring that all team members have equal opportunities for professional development and advancement.
4. Foster innovation through diversity of thought: We believe that diversity of ideas and perspectives is essential for innovation and success.

Actions to Achieve Our Objectives:
1. Implementation of equitable hiring practices: We are implementing equitable hiring practices that eliminate biases and increase the diversity of our candidate pool.
2. Development of training and awareness programs: We offer training and awareness programs on diversity, equity, and inclusion for all team members.
3. Creation of resource groups for minority groups: We have established resource groups for minority groups to provide support and foster community.
4. Measurement and tracking of our progress: We are measuring and tracking our progress on diversity, equity, and inclusion so that we can identify areas for improvement and celebrate our successes.

Conclusion:
Diversity, equity, and inclusion are core values at Bionavi. We are committed to creating a diverse, equitable, and inclusive team where all members feel valued, respected, and have the opportunity to reach their full potential. We believe that diversity is essential for innovation and success, and that a diverse team can provide better solutions to the challenges faced by low- and middle-income communities worldwide.

Bionavi Business Model Summary:

Mission:
To democratize access to neuro-navigation technology in Latin America by providing high-quality solutions at affordable prices to enhance the precision and safety of neurological surgeries.

Vision:
To become the regional leader in neuro-navigation, recognized for our innovation, quality, commitment to accessibility, and customer care.

Customers:
- Public and private hospitals of varying levels of complexity.
- Neurosurgery specialized clinics.
- Health service provider companies.

Value Proposition:
- Portable, easy-to-use, and accessible neuro-navigation systems: Designed to adapt to the needs of different medical centers, from large hospitals to specialized clinics.

- Accessories and Supplies. 

- Comprehensive support services: We provide technical assistance, training, and preventive maintenance to ensure optimal equipment performance.
- Personalized consultations: We help clients select the most suitable neuro-navigation system for their needs and budget.

Distribution Channels:
- Direct sales through our sales team.
- Collaboration with specialized medical equipment distributors.
- Participation in health sector fairs and events.

Customer Relationships:
- Focus on exceptional customer service, offering fast support, training, and personalized advice.
- Constant communication to understand customer needs and expectations.
- Building long-lasting relationships based on trust and mutual benefit.

Revenue Streams:
- Sales of neuro-navigation systems, accessories, and supplies.
- Technical support services, training, and preventive maintenance.
- Personalized consultations.

Marketing Strategy:
1. Participation in health sector fairs and events.
2. Digital marketing to reach a wide audience and generate leads.
3. Public relations to generate positive publicity.
4. Informative and educational content marketing about neuro-navigation.

Social Impact:
1. Improvement of precision and safety in neurological surgeries, reducing the risk of complications and improving patient outcomes.
2. Access to cutting-edge technology for hospitals in developing countries, enabling better healthcare delivery.
3. Creation of direct and indirect jobs in the region.

Sustainability:
1. Constant innovation in products and services.
2. Responsible environmental management in operations.
3. Commitment to the community through social and educational initiatives.

Economic Focus:
1. Competitive pricing: Offering neuro-navigation solutions with costs adjusted to the economic realities of Latin America, enabling more medical centers to access this technology.
2. Scalable business model: Designing a structure that allows sustainable growth, expanding our presence in the region, and increasing our customer base.
3. Diversified revenue generation: Combining equipment sales with support and consultancy services to generate recurring and stable income.
4. Strategic partnerships: Collaborating with healthcare sector companies to expand our reach and access new markets.
5. Investment in research and development: Allocating resources to continuously improve our products and services, maintaining our competitive advantage.

Conclusion:
Bionavi aims to transform the neuro-navigation landscape in Latin America by offering innovative, accessible, and high-quality solutions that benefit both patients and medical centers. Our business model is designed to generate a positive impact on people's health, drive economic and social development in the region, and ensure long-term sustainability of the company.

Bionavi Financial Sustainability Plan

The main objective of Bionavi is to achieve long-term financial sustainability, ensuring the growth and profitability of the company to offer accessible neuro-navigation solutions in Latin America. To achieve this goal, we have developed solid strategies in three key areas: diversification of income, scalability and expansion, and operational efficiency.

Diversification of Income:
To ensure financial stability, we diversify our sources of income:
- Sale of neuro-navigation systems: It constitutes our main source of income, with competitive prices and flexible payment models to adapt to different budgets.
- Technical support services: We provide technical support, training, and preventive maintenance to our customers, generating recurring income.
- Personalized consulting: We offer expert advice to help customers select the ideal system and optimize its use, generating additional income.

Scalability and Expansion:
We seek sustainable growth and expand our presence in the region by:
- Geographical expansion: We expand our presence in Latin America, penetrating new markets, and increasing our customer base.
- Development of new products: We research and develop new neuro-navigation solutions to meet specific market needs and stay at the forefront of innovation.
- Strategic partnerships: We collaborate with companies in the health sector to expand our reach and access new business opportunities.

Operational Efficiency:
We seek to optimize our resources and reduce costs through:
- Cost optimization: We implement strategies to reduce expenses without sacrificing the quality of our products and services.
- Efficient resource management: We maximize profitability by optimizing the use of human, financial, and material resources.
- Adoption of technologies: We incorporate innovative technologies to improve efficiency in our processes and reduce long-term operating costs.

Evidence of Success:
To date, we have obtained initial financing through our own funds and government and private grants. Additionally, we have made initial sales of our neuro-navigation systems to hospitals and clinics in Colombia, receiving positive feedback from customers.

Financial Projections:
We project sustained revenue growth in the coming years, driven by geographical expansion, the development of new products, and the diversification of services. Likewise, we expect to achieve financial profitability in the coming years, generating profits that will be reinvested in the growth and innovation of the company.

Conclusion:

Bionavi has a solid and well-defined financial sustainability plan, supported by income diversification, scalability, and operational efficiency. Initial evidence of success and positive financial projections support the viability of the plan. We are committed to responsibly managing our financial resources to ensure sustainable long-term growth and a positive impact on the health of people in Latin America.