Cancer curing via reverse DNA composition

Every year, in the time of giving charities in Egypt, you see many people deciding which organization they want to help, and more than 60% of people decide to help the cancer hospitals, do you remember Mr. Thatha, who gave his house and car, to help the poor sick children, coming to get the treatment, before cancer defeat their small weak bodies?

So I decided to learn more about Cancer, to be able to help exhausted souls, and I am thinking of combining cancer treatment with genetics, to look at cancerous cells from its base, and that matched my motivations.

My research focuses on understanding the Cancerous cell genetic structure, and using inverse genes composition to recompose the cell to be normal, it depends on genetic engineering and have two types, one is based on chain curing so that connected genes can be cured be recomposing only one. The second one is for leukemia and cancer types where it is not a connected tumor and these type is more complicated and need more development cause the cells are not easily detect able and it is not a chain curing so my research for rise will focus on the first type.

My project aims to recompose the genetic structure of tumors, to cure the genetic disorder leading to cancer, it aims to improve an effective way in detecting tumors, and I chose this way to be able to cure the cancerous cells by bringing it back to its normal status not by destroying it.

My solution goes through three parts:

·         The detection which uses nanoballs of different types to depending on this hypothesis (nanoballs can connect with molecules according to wavelength in special conditions like superconductivity, so it can be used to detect substances in body or blood).

·         After defining the cancer genetic disorder, a machine will reverse the process of the formation of the disorder using a laser programmatic system that uses electromagnetic rays for accurate objected and a simplified OECT  to detect the presence duration, after curing one, a correction chain will happen according to a mathematical programmatic way chosen out of huge data.

Example of output:

Binary representation: 10011100111001110010011100100111001001110011

Numeric code: 9127378100111001110011100100111001001110011100912836

Bug: AA

Way to solve bug: R-R-D-R-R-D-R-D-L

Bug energy: 912.836

·         Then comes the last part, curing the disorder reasons, and observing the patient to make sure the genetic disorder is no more chronic.

After the design, I started developing the final format to construct, so I connected my solution to previous researches: 

It's of a cube machine with five chambers in, the smaller is in the middle of the upper type of the cube, a convex mirror is emerging from it, inside the chamber a small laser producer, the chamber on its right contains the energy producer which is a water-energy machine or bio-cell connected to all chamber, on the extreme left there is the chamber of equipment contains up to 50 smaller boxes, below them there are two chambers same in size of the three combined, one of the is the computational part contains motherboard and a simple screen containing a huge data of codes, it's also connected wireless with a main frame computer, the last chamber contains the thermal producer which is connected to both the computational and laser

I made a questionnaire to about 100 high school and university students to get the audience opinion and thoughts about cancer, gene engineering,..etc.

The mathematical basis is :

1) 

The Needleman-Wunsch algorithm which is a dynamic programming algorithm that finds the optimal global alignment of two sequences. It works by computing a matrix of scores that represent the similarity between all possible pairs of prefixes of the two sequences.

2) Some cases may not be suitable for Needleman-Wunsch algorithm, like this:

ACGTACGTACGTACGTACT where there is a missing G so the solution is either duplicating a G and adding it to the required part but you can only destroy if the part is in the end, connect the end to the start, reverse all, or duplicate the last part(s)

Thus we will use this original way:

Let S be the input sequence of length N. Let i be the position of the missing G in S.

If i > 1, then the modified sequence is: S[1:i-1] + S[i-1] + 'G' + S[i:N]

If i = 1, then the modified sequence is: S[i-1] + 'G' + S[i:N]

where '+' denotes concatenation and S[i] denotes the nucleotide at position i of S.

My project is mainly made to serve :

1) People with DNA abnormalities in a connected mass.

2) People with tumors or other types of cancer during the time of treatment or after treatment care.

We were mostly involved in our community and effected with the numerous advertisements and programs on all social media forms that address the struggles that cancer patients face, also the rise of genetic engineering and projects like CRISPER.  

Because currently the computational program is complete and was tested several times, but in the phase of development, all the experiments are done, materials for the main machine are ready, and the machine is being constructed. Also both the mathematical base and the biological base were put into test and proved their validity.

Due to the precautions and requirements of that project, all tests currently are being done on data without doing the last part injecting the modified gene to a human body, so it's currently still not fully trusted to be tried on actual patients.

I am mainly applying to be able to do further researches and development of my project, I believe those points may be helpful for me:

• Join a class of impressive peers that act as a trusted support group, offering inspiration and guidance.

• Join a powerful network of impact-minded leaders across industries and sectors, with dedicated spaces to meet year-round and during Solve’s flagship events such as Solve at MIT.  

• Gain exposure in the media and at conferences.

• Access relevant in-kind resources such as software licenses and legal services from Solve supporters. 

First of all, despite all the evolution in the field of genetic engineering nowadays, it was mostly targeted toward the development of a specific characteristic or property, but it wasn't thought of as a possible cure, which make the whole idea totally new 

Also, maybe the idea of having a computational program is not new but the full machine is an original project as a set of equipment collected in one.

And some of the mathematical bases are original theories and formulas, they were not used in this field before, even though they if course existed but as a set of procedures not a gene related theory 

I plan on finishing the first product with all its systems and developments and get it official in June 2024, it may seem long time but as a group of high school students, it worth it 

Also we will take about 3 months to manage the markets and so ( even though we already established three products and working on the fourth ).

We aim to establish this project as treatment and after treatment system, it will be firstly established in the universities colleges and research institutes.

My project is mainly related to those UN indicators :

Achieve universal health coverage, including financial risk protection, access to quality essential health-care services and access to safe, effective, quality and affordable essential medicines and vaccines for all

Support the research and development of vaccines and medicines for the communicable and non-communicable diseases that primarily affect developing countries, provide access to affordable essential medicines and vaccines, in accordance with the Doha Declaration on the TRIPS Agreement and Public Health, which affirms the right of developing countries to use to the full the provisions in the Agreement on Trade-Related Aspects of Intellectual Property Rights regarding flexibilities to protect public health, and, in particular, provide access to medicines for all

Increase the access of small-scale industrial and other enterprises, in particular in developing countries, to financial services, including affordable credit, and their integration into value chains and markets

Enhance scientific research, upgrade the technological capabilities of industrial sectors in all countries, in particular developing countries, including, by 2030, encouraging innovation and substantially increasing the number of research and development workers per 1 million people and public and private research and development spending

Our project will mainly effect the ways of DNA abnormalities treatment, as it will open the way to treat some abnormalities will thought to be untreated, and prevent the side effects of some past treatments like chemical treatment of cancer.

It also will effect the system of after treatment care which may be poor in many places regarding many diseases especially those which may require life long care.

1) Computational program for detecting the bug in the DNA sequence, calculating number of steps needed to solve it, way of correction and amount of energy needed if it needs destruction.

2) Machine for gene correction ( may be via OECT-nanoballs technique or laboratory correction.

3) Laser machine with high accuracy

Currently, our team is small but diverse, as in our previous projects, all the members were from Egypt, Colombia, USA, Japan, China, Mexico, Jordan,....

But as our team is still small, not well established as a start up, and of young students from high school, we may still lack of some principles of good diverse team.

However, our policy in the team is simple but effective, we focus on our work, whether we agree or disagree, we focus on our work, the team is mainly for scientific research, thus why to create hatred on side talks, we surely work on having good relationships with all members, and there are strong friendships between many members on all projects, but again this is all about science, we don't allow long  side talks during work, and members are advised to discover each others as a scientists first, then after some time of working together, on social gatherings, members will approach each other and become friends after valuing each other skills and good manners, thus after long hours of work and discovering each other, they won't hate each other based on gender, nationality, religion, or so, and any talks will be always accompanied with respect to the other side.

Key Partners 
< Experiments and trials
hostel
< Company producer
< Materials source (longtime)
< Sponsors and funding

Key Activities

< Material preparation
< Producing:
* Laser Machine
* 1st computational program
* 2nd computational program
* Skin protection shield
< Selling

Cost: About 65 USD for the first production, but it will be lower after that due to the materials agreements we are having.

It will be sold firstly as a part of research centered agreement ( non-profit ), then it will be through our start-up, this is one of our interactive packages we sold before from which you can get an idea : 

This is a package of many great ideas to help the learn about Parker Probe, it is currently available only in English, but there will be Arabic, Chinese, Japanese, French, and German versions soon.  Its price is equivalent to 20 EGP, and we put in our mind all the ages of the children, and the differences in learning between each child, so we didn't rely on only one method, but 9, all in one package, and are completely made by the two students if nothing else said, so start the engine and GO.

Detailed Project Description

1. Cartoon short video about the project. " Video"
2. Eugene Parker is talking to you through deep fake."Video"
3. Help Parky!! A paper based game; it aims to teach the children more about Parker's journey, so they are going to put the events in the right order based on what they conclude from the clues given, More suitable for children aged 10 and up.
4. You are the astronaut. A mobile app encouraging the children to explore more parts of the space in order to achieve certain goal according to his interests, for example: (Saving the princess, being the king of the space, defeating the enemies, ……..), it is for the suitable age to use phones. 

Example:

• Save the princess
• King of the space
• Defeat the enemies 

The space is yours. AI based software helps the child to simulate being in a journey like Parker, it is easy to use and mixes between amusement and information.Talk to me. AI simulator serves as Parker's character to answer the children question.

7. Parkopoli!! A paper based game looks like monopoly but with places Parker passed by through his journey, some rules are a bit different, you should say at least three info about the place you step on or you will be charged money.

8.Parker's Autobiography. This is a short book with about five lines and a picture on each page that serves as an autobiography of Parker. Here is an example of what one of the pages in the book might look like:  Page 1: My name is Eugene Parker. I was born in Michigan in 1927. I went to college at Michigan State University. I studied physics and got my PhD from Caltech. I discovered the solar wind in 1958. [Picture of Parker]

9.Knowledge official website. The official website of Knowledge company in which we share the info about different topics and projects.

1. Sustained Donations and Grants: Many non-profit organizations and projects rely on donations and grants from individuals, philanthropic foundations, and government agencies to fund their work.

2. Selling Products or Services: Businesses can generate revenue by selling products or services that are related to their mission or expertise.

3. Service Contracts to Governments: Some organizations may be able to secure contracts to provide services or expertise to government agencies or other organizations. 

4. Raising Investment Capital: For-profit ventures may seek to raise investment capital from venture capitalists or other investors to fund their growth and development. 

Currently, this project is still considered a newborn as it was mostly in the phase of individual research and development, anyway I will provide examples from our previous projects.

1) Joining contests or scholarships which may give us funding, technical and scientific support, or be our media window.

2) Conferences and science fairs from which we were able to get sponsorship.

3) I started learning investment last year, and I had some successful trials, so I may start next August if I became sure of my abilities.

Some examples:

Project 1 : Ant robots : Technical support grant, two sponsorship, Funding and mentoring from the government.

Project 2 : Covid-19 detectors : Official recognition from the government, scientific support during research, access to data, media window, mentoring.

Project 3: Parker solar probe Package : Marketing and media window.