TermoFly

Fever monitoring has not radically changed since the thermometer's invention in 1867 in primary and secondary healthcare, nor at-home usage. Accurate temperature monitoring has shown crucial for diagnostics, and prevention of bacterial, and viral infections, and their predictions. There are no such solutions on the market that could monitor the temperature continuously in real-time, with low energy consumption, not depending on the wifi or Bluetooth connectivity. Millions of people face a lack of access to primary healthcare, especially in low- and middle-income countries. They stay out of the possibility of the right treatments because they don't have the right and low-cost tools for primary health measurement. In babies, fever trends showed also essentially for diagnostics. In the early months, babies respond differently to a medication, which could be shown in the fever trends. In the USA every 6 min medication mistakes happen in hospitals in children under 6 years old.

ThermoFly is a system for continuous body temperature monitoring. Its consists of a sensor band, a temperature sensor box with a QR code for a user application, or data transfer to the doctor. The sensor box could be easily removed, so the band is washable and reusable. In the first use case, the system might be used via a user app and requires a wifi connection for alarm set up and medication dosage notification. The sensor sends the data to the user's smart device via Bluetooth. Users are able to export the temperature graphs from the system and send it to the doctor via the same QR code. In the second use case, the system could be used as a temperature holter, which does not depend on wifi connectivity and Bluetooth to acquire the data and measure the temperature. Alarms will be set up by doctors and activated on the device itself, and fever trends might be transferred to the doctor via Bluetooth on the examination by QR code. The altering system is helping patients at home and avoiding mistakes at hospitals, making stuff management easier and saving patients' data automatically (digital temperature lists). The system allows usage of the several devices in one space with a sensor hub. The battery lifecycle is designed to serve 3 months in continuous monitoring or up to three years in separate usage (with firmware that dictates sleep and wake-up mode, as well as the frequency of the data transferring). The existing solutions on the market are for single use, with blasters which usually irritate the skin, other ones are gadgets or systems which need frequently battery recharge. In the first use case, the patients are collecting the data, secured by a QR code that activates the app on their phones and saves the data on their devices. In the second use case, the system could be recommended by doctors at discharge from the hospital or the ambulance for temperature monitoring, and used in hospitals for in-house patient monitoring. Primary health care systems are owners of the data which helps them understand the patient's conditions, and get alarms and predictions about certain diseases. The second use case is specially designed for low- and middle-income countries, where the people do not have access to the measurement tools which could help in more effective disease diagnostics.

The system is designed for people living in countries with frequent pandemics, and mass infections, elderly people or parents with babies in rural areas, and people with chronic diseases with frequent inflammations that cause an increase in temperature. ThermoFly is a low-cost, fit-for-purpose system with data shareable across information systems, and streamlined for data collectors-doctors. The system is designed to be reusable, washable, easy to maintain, and used as a monitoring tool during a certain period of time when people do not have wifi, electricity, or other smart devices. It is secured for each user-patient and could be set up by doctors depending on the desired outcomes. ThermoFly gives accessible insights for health care providers, and it can be used to optimize the performance of primary health care. With the prediction (machine learning) algorithms, it could balance the pressure on the frontline health workers and save lives in different pandemics or mass infections. 

Our team was fully engaged during the beginning of the Covid19 pandemic in the Republic of Serbia to invent solutions that will improve the conditions of the health workers at the frontlines. We have developed the solution Doctors for Doctors, for monitoring the physical and mental health of the doctors during the pandemic and offering the right help in critical situations. The project was supported by the Serbian Government and Ministry of innovation and technological development of Serbia. At the same time, team members and co-founders of Baby FM dr Ivan Soldatovic and Vladimir Jeftovic were engaged in the development of the world's first bracelet for covid prediction AVA (Switzerland). Ivan Soldatovic is a consultant for international companies for clinical trial designs (Roche, Phizer, LaRosche Possay, CoreMedic, etc) and a professor at the Faculty of Medicine. Vladimir Jeftovic is a former employee at Amazon, who was engaged in Alexa voice recognition system development. CEO and co-founder Tamara Papic was engaged in business development for several international companies, and experienced in project management, innovative ecosystem development, etc. The team member prof. dr Nenad Jovičić was engaged in international and national IoT solution development and design of custom electronics, as well as prof. dr Goran Stojanovic. Milijan Ćelić who is the team lead for software development was engaged in several projects for USAID, and EBRD, creating the solutions which transfer the knowledge from innovative systems to the industry in Bosnia and Hercegovina. Our team is working and creating solutions from the Balkan area (low- and middle-income countries) and understands the challenges which could be applicable in all other areas around the globe. 

Serbia is a middle-income county and does not have proper access to finance for the implementation and development of solutions which could improve the well-being of the citizens and their primary health. Our solution needs financial support to step from a pilot to scalable product, which means finishing the clinical trials and certification of the product for international markets. 

Baby FM's first invention is the sensor with silver threads for reliable and accurate temperature monitoring. Silver threads are the medium between skin and sensor.  The designed system has the following advantages: no irritation, antiallergic, a larger surface for temperature measurement, and a stable system for temperature monitoring. The second version ThermoFly is upgraded with double sensors which measure the temperatures of the body and environment with an AI algorithm to correct the temperature in order to get the most accurate monitoring. ThermoFly aims to determine the position of the arm and make measurement estimation and corrections. 
ADVANTAGES: Reusable and washable band / Controlled remotely from several devices/ Temperature-medication graph export/ Telemedicine service/ Certified organic materials used for sensor band/ Personalized app

The battery lifecycle has its own firmware for sleep and wake-up conditions, as well as for frequency of data transferring or saving (depending on the use case). 

QR code is used to secure the data of the users and activate the user app which is connected to a certain sensor. The same code will be used for data description by doctors in primary health care.

The system will be trained with different temperature trends to understand are the infections are viral or bacterial, and to predict certain body conditions like overheating, fever convulsions, etc.

ThermoFly is catalytic because it radically changes temperature monitoring in a much simpler and more accurate way. Users, patients, and children will be able to use it without impacting other everyday activities.

Digitalized temperature lists and temperature trends will save healthcare workers' time and help the development of different predictive algorithms

Predictive algorithms will help in the development of telehealth solutions and solve problems of the lack of the doctors in primary healthcare and assessment of the right treatments

Early detection of the infections will result in a lower number of cases and less mortality

Real-time data will help in understanding the drug's effect on different conditions and metabolic responses 

Developed predictive algorithms for pandemics, bacterial and viral infections

The lower number of infection cases in healthcare workers and in certain societies

Digitalized patient data will help in diagnostics in hospital and home usage

Statistics on the effectiveness of the healthcare workers

Continuous temperature measurement especially in periods of pandemic or mass infections will show the metabolic response to different medications via temperature trends. That means that stakeholders from the pharmaceutical industry will be able to better understand the medication effect in real-time or test it in clinical trials using the same system. Our solution will impact the whole health care system including the treatment of the disease and diagnostics.

1. Patients will have a simple, fit-to-purpose system for home usage, which will not affect their everyday activities
2. Telehealth, and alerting and notification support
3. Doctors will have better insight into the patient's condition
4. Alerting system and prediction models that will help in diagnostic
5. Pharmaceutical companies will have a better understanding of the medication effect and drug development
6. People will have more personalized solutions which will result in better primary healthcare and overall wellbeing

Baby FM has developed its custom PCB and sensor case to cut the cost of mass production and achieve maximum accuracy. It uses a Bluetooth module for data collection and transfer. Data storage and transfer are based on peer-to-peer communication between the sensory devices and mobile phones (or tablets in the clinical environment). The data could be measured and saved in the system memory in cases where there is no conectivity with other devices and networks. The silver threads woven in the cotton band ensure good thermal transfer between human skin and the sensor. It has been tested in vitro and achieves excellent measurement reliability. Two clinical studies are ongoing and perceiving excellent results at University Clinics in Belgrade, Republic of Serbia.

In the first use case, the patients are collecting the data, secured by a QR code that activates the app on their phones and saves the data on their devices. They are owners of the data which enables them to set the alerting and notifications system and export the temperature graphs and communicate with the doctors.

In the second use case, the ThermFly system is recommended by doctors at discharge from the hospital or the ambulance for temperature monitoring, and used in hospitals for in-house patient monitoring. Primary health care systems are owners of the data which helps them understand the patient's conditions, and get alarms and predictions about certain diseases. The second use case is specially designed for low- and middle-income countries, where the people do not have access to the measurement tools which could help in more effective disease diagnostics.

The company CEO is female, and the company from its beginning values women's leadership and equality. The team is open to all marginalized groups and their inclusion if they address the professional skills for company development. Baby FM is trying to create an environment in which all members of a society are welcomed, respected, supported, and valued.

1. B2G-  pre-admission and on discharge from hospital patients are recommended ThermoFLy fever monitoring and doctors telehealth service covered by Governmental primary health care program. 
2. B2B - SaaS subscription-based model with revenue share with distribution partners.
3. B2C- direct sales, and distribution with a freemium model for the app

The company already has two ongoing clinical trials and signed an agreement with one of the largest healthcare private chains Acibadem Bel Medic in the Republic of Serbia.

The company will apply for European grant programs as well as programs at the Innovation fund of the Republic of Serbia.

The investment round is open.

Baby FM is the winner of the ImagineIF competition as the best startup in the healthcare sector in 2020 in the Republic of Serbia and one of 15 global finalists at Innovation Frum Cambridge 2021.

Baby FM  is granted by the Accelerator program Raising Starts by the Swiss Government and Science Technology park Belgrade for prototype development.

Baby FM is granted by the Star Tech program supported by the Cabinet of the Prime MInister of the Republic of Serbia and NALED.