Resolving Time Paradox

String-matter atomic analogy that emerges Discrete-time and Three-dimensional structures by Eigen-rotation of One-dimensional String-segments, resolves Time paradox in Particle scenario, that is the Root cause for Levinthal's paradox.

This Scientific-solution for Technological-solutions is to resolve Time-paradox by String-matter Atomic Analogy on unifying fermions with fields and modifying quantum string theory, provides three technological-solutions to healthcare by resolving Levinthal's paradox. 3D/4D structure of Eigen-rotational Quantum dynamics of elements and isotopes, with two-dimensional abstractions are accommodated in an Integration table with Periodic Table. These technological solutions are:

• DTWRS Spectrometry and Diagnostic Devices from this solution identifies new properties of elements and molecules in multi-omics, in cohesive with Mass spectrometry and NMR spectroscopy, while a database for the Wave Bundle Patterns of all elements and molecules by machine learning to be deployed for further applications development. These properties are included in the integration table, whereas another table is developed to accommodate the String-matter molecular structure of all molecules of interest and their new properties.
• Realtime Molecular De-assembly therapy from this solution by utilizing Wave Bundle Pattern Database; inclusively provides applications for the Neutralization of coronavirus and Curative cancer treatment.
• Unique Portable Real-time Digital (UPRD) Medical Record System for Decision support to real-time healthcare applications by combining applications from the said technological solutions with other Realtime healthcare applications.

Nature of time in particle scenario is the basic problem, as nature of fundamental matter ascribed to describe the nature of universe, expresses that time emerges external to the dynamics of zero-dimensional particle, resulting time paradox, whereas in one-dimensional string-matter, ‘Time’ and three-dimensional structure emerges with the eigen-rotation of string-segment, implying ‘Time’ is discrete, relative and holarchical.

Thus, Levinthal's paradox in protein folding is resolved and incidence of protein folding is traced back in relative reference time, to redefine mechanism and new molecular pathways for identifying causatives of diseases. This proceeds with development of devices to monitor and to regulate in-vivo dynamics of target biomolecules, adapting the mechanism of Dual-wavelength Three-dimensional Wave-bundle Resonance Sensing (DTWRS) Spectrometry, after building database for wave bundle patterns of elements and molecules, by this spectrometry.

Currently, as therapeutic and investigative devices work only on external reference-time and device-time, molecular dynamic events sequencing is not possible to confirm molecular pathways to identify the causatives for specific diseases and disorders. To solve these problems, require:

1. Development of new groups of therapeutic agents, Diagnostic reagents and other Biomedical reagents, in cohesive with a Dual-wavelength Three-dimensional Wave-bundle Resonance Sensing (DTWRS) Spectrometry.

2. Development of new Realtime therapeutic modalities and instrumentations, inclusively for Curative cancer treatment, and Coronavirus neutralization; that uses data from this Spectrometry for molecular regulatory operations, in real-time.

3. Decision support in healthcare by UPRDMR System, while installing these devices.

Altogether, this solution serves the patients who are having unique portable real time digital medical records, while assisted with decision support by healthcare providers. This service reaches the patients through following chain of sectors in sequence:

• Biochemistry Labs:
• Molecular Labs:
• Drugs and Biologicals Developers:
• Biomedical Instrumentation developers:
• Healthcare Regulators:
• Healthcare Providers:

Are positively impacted by the advancement of this solution, while proteomics is specifically focused. Exploring specimen samples with DTWRS Spectrometry, in cohesive with Mass spectrometry and NMR spectroscopy is expected to be confirmatory for this solution by defining new properties for elements.

Are positively impacted by new molecular modelling for molecules of interest, that proceeds with this atomic analogy to confirm the characterization of molecules with the inclusion of new properties identified by DTWRS Spectrometry.

Are positively impacted by the identification of molecules of interest for healthcare applications after re-characterization in Biochemistry and Molecular labs, inclusively by DTWRS Spectrometry followed with animal testing and clinical trial, for the development of new drugs and biologicals.

Are positively impacted by developing new devices, while the identified target molecules of interest need environmental activation from external source, while performing real-time therapeutic procedures.

While serving this solution to end users of patients; this implication needs regulative proceedings, and thus this sector is positively impacted.

Are positively impacted by the inclusion of new therapeutic and diagnostic modalities and methods by the inclusion of new drugs, biologicals and devices, to patients.

Needs-analysis inference in specific to the populations of patience, concludes the requirement of following, while reasoning the adaptation of Precision medicine:

1. Unique Portable Real-time Digital (UPRD) Medical Records to prevent Healthcare data error, while providing decision support in real-time, needs a ‘Worldwide Software Infrastructure (WSI) Platform for Realtime Healthcare’, accessible by UPRDMR-Id cards through Vector-IoT devices that are installable at Public and Private localities and operational by consensus with the concerned patients. This platform has Digital Cluster Control (DCC) Nodes of Hybrid Cloud Servers for each 3 to 9 Digital Healthcare Centres to transact all Personal-health, Public-health and Corporate-health applications and data, inclusively for, ‘Human Coronavirus Harmful Mutants & lineage Control (HCHMC) Program’ to WHO. Thus, adapting measures to spread the need for this solution to population, is on process.

2. Requirement of Realtime Digital Healthcare (RDH) strategy includes provisions for handling the Realtime instances and responds between patients and healthcare system, and the devices for real-time investigations and therapy, that extends up to man-machine interactions with in-vivo biomolecular dynamics, inclusive of Dual-wavelength Three-dimensional Wave-bundle Sensing (DTWRS) technologies from this solution.

3. Requirement for the adaptation for Realtime Decision support for Healthcare providers needs methods for the integration of UPRD Medical Records with Realtime Digital Healthcare strategy.

A progress report that is assigned with 5 phases to develop this solution indicates the current status, as follows:

Phase-1:

An Integration table with Periodic Table, is developed to accommodate the String structure models of all elements, that includes both three-dimensional structures with four-dimensional representations by Quantum Eigen-rotational dynamics for each element, along with abstractions in two-dimensional representations.

This Phase is on completion.

Phase-2:

Integration table is extended to accommodate the structure of all Isotopic variations. This phase is on process.

Phase-3:

Another table is developed, to accommodate String-matter molecular structure of all molecules of interest. This phase is also on process.

Phase-4:

Functional-prototyping of Dual-wavelength Three-dimensional Wave-bundle Resonance Sensing Spectrometry is developed to explore elements and molecules by Wave bundles of wavelets emitted by activating elements and molecules of compounds, in correlation with Mass spectrometry and NMR spectroscopy, to validate this solution. This phase is strategized but not started.

Phase-5:

Building a Database for the Wave Bundle Patterns of all elements and molecules, while identifying elements and molecules by machine learning to proceed with further applications developments and utilizations. This phase is not started.

This solution has evolved by the science of an alternative cosmological paradigm of ‘String-matter Universe’.

As per this paradigm, existing three-dimensional universe might have created from two-dimensionally distributed one-dimensional string-matters, on transfer of elastic potential energy, for the onset of eigen-rotation of strings, while time and three-dimensionality, emerges. Thus, three-dimensional objects that builds this existing universe is descriptive as quantized structures of Triangular Bi-Pyramidal (TBP) branes between nodes in the string-matter network of segments that are differentiated as elements with specific pattern of string-segments framework as scaffold for each element. While these elements are activated by elastic potential energy by transfer of string-segments, an eigen-rotational wave propagates in a string segment that detaches from the nodes unilaterally and connects to nearby another node in an element or molecule to activate it and so on. Structure of these propagating eigen-rotational waves can be quantized as Spiral Tetrahedral (ST) branes. Parameters of TBP branes and ST branes in point of time while observed by a specific array of detectors in tetrahedral senor units to sense the attributes by Dual-wavelength three dimensional waves in strings from elements and molecules; is the core of this technology that has been developed from this paradigm. This implies with the development of Dual-wavelength Three-dimensional Wave-bundle Resonance Sensing (DTWRS) Spectrometry and its applications. First application proposed on this spectrometry is the identification, isolation and purification of biomolecules of interest for the development of Locality-based Protein Subunit Surface (LPSS) Vaccinations.

As this solution is mainly for real-time applications, Worldwide Realtime Digital Healthcare Software Infrastructure (WRDHSI) Platform is imperative for the implementation of this solution to the population. Thus, deployment of pilot units of local native hybrid cloud server network of Digital Cluster Control (DCC) Nodes with clusters of nearby 3 to 9 Digitizable Healthcare (DH) centres of Hospitals, Nursing homes, Clinics and Primary Healthcare centres as clients; is the pre-requirement for launching this solution.

While launching this solution, number of Individuals served by this solution may be calculated in average by the number of DH centres installed in this WRDHSI Platform.

This may be in the next year if the pilot unit installations happen in the current year, for that the architecture of this WRDHSI platform is ready already.

The first application of DTWRS Spectrometry, from this solution is for identification, isolation and purification of biomolecules of interest from compounds of interest to develop Locality-based Protein Subunit Surface Vaccines (LPSSV). This to be distributed through this WRDHSI platform while the production may start with a minimum of 1 to 2 crores in next year for the distribution to the population, as there is urgent requirement of this vaccination.

Development of functional prototype for Dual-wavelength Three-dimensional Wave-bundle Resonance Sensing (DTWRS) Spectrometry at MIT is expected to make remarkable impact on the developments in biochemistry that is inclusive of biomolecular study and thus this objective is the impact goal of the entire project.

To achieve this goal of developing this prototype at MIT, includes the following steps:

• This task starts and iterates with listing of components and devices for instrumentation. This includes components source listing and adaptation requirements.
• Subsequently proceeds with the assembling of this functional prototype that iterates with required modifications.
• This proceeds with the testing of devices and units and configuring them as per requirements. This process also iterates.
• Next step is to program and to update program for the Sensor Unit and this step also iterates.
• Further to this, testing of the spectrometric functionality of this instrumentation to be performed with iteration. During this spectrometric functionality testing and subsequent testing of specimen samples, the data is subjected to machine learning for securing wave bundle pattern from elements and molecules.
• Subsequently, upgradeability assessment for each cycle to be performed before licensing to manufacturers.

Thus, expectations for sustainable development in biochemistry that has huge impact on healthcare towards precision medicine, whereas development of this impact goal is agile.

As the Digital Public-health applications in WRDHSI platform converges public-health data to WHO, the public-health indicators are assigned and used by WHO in real-time, with location-based specifications and regulatory guidelines. These indicators may include incidences of pandemic, epidemic and endemic infectious diseases, Metabolic diseases, Malignant diseases, Genetic disorders and others.

As this solution makes major impact in biochemistry developments, it is a huge benefit for healthcare and other life sciences.

Thus, development of Precision Medicine advancements with the inclusion of DTWRS Spectrometry in Healthcare system, progresses on this impact goals is measurable by these indicators of WHO, by WHO.

This implies that, sustainable development goals that fit into this solution is more on SDG 3; that is Good health and well-being, is specifically focused on Coronavirus control and Curative cancer treatment.

Sequence of utilization of applications from this solution are proposed in the order of:

1. Applications to develop Locality-based Protein Subunit Surface (LPSS) Vaccinations.

2. Applications to develop therapeutic agents end investigative reagents for many other diseases and disorders.

3. Realtime therapeutic modalities for curative cancer treatment and coronavirus neutralization.

Thus, the measurable indicators on SDG 3 are more specific to:

• Reduction of mortalities in pandemic, epidemic and endemic incidences.
• Reduction of mortality in malignancy.

As SDG 3, ‘Good health and well-being’ is prime for other sustainable development goals, this solution also promotes many other sustainable development goals, indirectly.

Some of the applications installed at WRDHSI Platform to provide this solution to patients at Inter-national borders and Sup-national borders, require geopolitical resolutions across the borders, for the benefit of the patients. In this context, issues across sub-national borders can be resolved easily, whereas issues across international borders are not easy to be resolved. Thus, accomplishing these goals for the patients from these areas may get delayed, while deployment of local native hybrid cloud server of Digital Cluster Control (DCC) Nodes with clusters of nearby 3 to 9 Digitizable Healthcare (DH) centres of Hospitals, Nursing homes, Clinics and Primary Healthcare centres at these areas may be difficult or even impossible in certain areas.

Thus, along with this application development from this solution, this platform development and deployment also to be in parallel, to mitigate these barriers, while implementing.

1. Dr. Jayakar Joseph Johnson, Medical graduate and was practicing surgeon (Profile at: http://orcid.org/0000-0003-2936-8231) is the Principal Investigator, who evolved this solution while working in full time for Realtime digital healthcare, that commenced on, 1990. Due to the requirement of real-time biometric identifier from DNA for Unique Digital Medical Records, he started exploring alternative cosmology from 2007 onwards and arrived this theoretical solution to proceed with implementation by building a global team. During this period, all developments are well documented and secured for outsourcing. Established communications with EMSL to perform experimentations after the development of functional prototype for the instrumentations of this spectrometry. This work is carried out at Johnsons Medicom Pvt Limited from 1995 onwards on registering this company.

2. From 1995 onwards, Dr. A. Jayanand M.E., PhD in Computer Engineering, is providing consultancy in computer science.

3. From 2006 onwards, Dr. D. Sam Harison M.E., Ph.D. in Electrical and Electronics Engineering (EEE) is providing consultancy in electronics.

4. From 2018 onwards, Allen Lloyd Francis M.B.A. (Systems), B. Com; providing project coordination in part time.

5. From 2019 onwards, Dr. S. M. A. Shibli PhD in chemistry, Professor, Department of Chemistry, University of Kerala, is providing consultancy in Chemistry.

6. From 2019 onwards, Dr.V. Vipinlal PhD in chemistry, University of Kerala, is providing consultancy in Chemistry.

7. From 2020 onwards, Dr. Y. Bakthasingh Lazarus PhD in Microbiology, Grace College, Kaliyakavillai; is providing consultancy in Microbiology.

As the development of this solution has reached the stage of implementation by developing applications; sets and sub-subsets of team-members to be organized as a global team for the agile development of applications from this solution.

Currently working as a partner with Johnsons Medicom Pvt Ltd, India, CIN: U72200KL1995PTC009161, registered on, 26 June 1995, with the objectives to provide basic facilities and background support for researchers working on Digital Healthcare to develop software and hardware. Academic and faculty supports are being provided by Grace institutions Padanthalumoodu, 629153, India; where the author of this work is a guest lecturer.

To build a global collaborative partnership network the same WRDHSI Platform shall be adopted with specific DCC notes dedicated for research network on this solution, has been proposed. This may include to collaborate with, Integrated Electron microscope developers, Integrated Mass spectrometry developers, Integrated NMR spectroscopy developers, Integrated Flow cytometry developers and any other integrated biomedical instruments developers, for new applications development from this solution, while implementing this project.

Persistent Pandemic by Coronavirus is causing Negative socioeconomic impact worldwide, due to:

• Increase in sickness among populations.
• Increased Healthcare expenditures.
• Increased Joblessness.
• Less accessibility to healthcare centres.
• Constrains in getting educational opportunities.
• Lack of genuine adequate social contacts and social isolations.
• Increased business losses and financial constraints.

These are the precipitating factors for the increase in unstable mental health among society, and more impacting on the younger generation as their educational activity is hampered much. This is prevalence to children between age group 5 to 18.

In Developing countries and Least-developed countries; as the female children are not considered as the earning member by education-based job opportunities for their future family establishment, their educational opportunity is much denied than for the male children, while women empowerment measures are inadequate. Thus, constrains in getting educational opportunities among girl children is more prevalent than boys and mental impairment is more common among girl children.

This is augmented in pandemic situations; and due to the persistent pandemic situation by coronavirus, future of 5 to 18 age group of girl children is bleak.

Thus, the following Corporate Social Responsibility is adopted in this project:

This solution of resolving Time Paradox by Alternative Atomic Analogy, is applied for the development of many new Therapeutic and Investigating devices for Realtime Digital Healthcare, that needs to be installed in a Worldwide Realtime Digital Healthcare Software Infrastructure (WRDHSI) Platform, constituted by a network of Local Native Hybrid Cloud Servers of Digital Cluster Control (DCC) Nodes with clusters of nearby 3 to 9 Digitizable Healthcare (DH) centres of Hospitals, Nursing homes, Clinics and Primary Healthcare centres; as clients. These nodes and centres transact Unique Portable Realtime Digital Medical Records (UPRDMR) of patients, to patients and their healthcare associates, in real-time. This platform can be preferably developed by distributed virtual offices working from home that is much applicable for girl children, between the age group 13 to 24.

As this platform provides services for public-health, corporate health, and personal-health, the WHO can directly provide feedback guideline support up to DH centers level and regulatory guidelines to Government healthcare regulatory authorities, much effectively during pandemic, endemic and epidemic situations.

As the architecture of WRDHSI platform has been already developed, while licensing for DCC nodes worldwide with a very nominal licensing fee, a women empowerment policy is proposed by the corporate social responsibility of this project. In this, 13 to 18 age group of girls are continuously getting benefited as intended to subsidize the licensing of DCC nodes to women entrepreneurs with 50% subsidized, whereas with 75% subsidized for those within the age group of 24 from Developing and Least-developed countries worldwide. Thus, growing girl children from this age group are more benefited sustainably by getting training and job opportunity in this massive and regulated healthcare data processing and programming, that is much suitable for women, and this is expected to uplift and standardize global Digital health towards worldwide Realtime digital healthcare, with more benefits for girl children between the age 13 to 24 in online job opportunities.

If awarded, the team will utilize the award money to deploy pilot DCC units to build this WRDHSI Platform for installing this solution rather than prioritizing the development of applications for this solution and thereby intended to prioritize the benefits to girl children who are affected more in this current situation.

This project has 4 solutions in that one is the central solution that is a scientific solution and the other three are specific technological solutions. These solutions along with Corporate Social Responsibilities (CSR) for each solution, are listed as follows:

Solution-1: A central scientific solution to resolve Time Paradox by String-matter Atomic Analogy.

CSR on this solution is to distribute all new educational resources developed on this to educational institutions without profit.

Solution-2: A specific technological solution to resolve the constraints on the progress of advancements in Chemistry, by developing Dual-wavelength Three-dimensional Wave-bundle Resonance Sensing (DTWRS) Spectrometry.

CSR on this solution is to distribute DTWRS Spectrometry technology for any Environmental studies without profit. Any new educational resources developed on this solution to be distributed to educational institutions without profit.

Solution-3: A specific technological solution to resolve the unavailability of Realtime Molecular De-assembly (RMD) therapy, applicable inclusively for Coronavirus neutralization and Curative cancer treatment, by developing Integrated Dual-wavelength Three-dimensional Wave-bundle Resonance Sensing (IDTWRS) Feedback control devices.

CSR on this solution is to distribute Realtime Molecular De-assembly (RMD) technology to Least Developed Countries in subsidized rates. Any new educational resources developed on this solution to be distributed to educational institutions without profit.

Solution-4: A specific technological solution to resolve the hurdles in real-time decision support for healthcare by implementing a Unique Portable Real-time Digital (UPRD) Medical Record System at WRDHSI Platform.

CSR on this solution is to provide subsidized licensing to deploy DCC nodes and to train the teams of Women entrepreneurs from Developing countries and Least-developed countries with 50% subsidized, whereas with 75% subsidized for those within the age group of 24 to build WRDHSI Platform by more with Women-empowered workforces of distributed virtual offices working from home, is proposed, in that growing girl children of 13 to 18 age groups are more benefited. Any new educational resources developed on this solution to be distributed to educational institutions without profit.

Thus, a wide range of social benefits can be derived from these solutions and to be distributed to society, asper the corporate social responsibilities assigned in this project, apart from for-profit applications.

If awarded, this team will utilize the award money to advance the developments in solutions 1 and 2 to develop further on this String-matter Atomic Analogy and DTWRS Spectrometry.