Saving maternal & infants victims

I propose a developing a novel synthetic vaccines that can acts as life saving agents in everyone victims especially pregnant women and newborn children (<5 yrs) those are suffering from one of the deadliest prevalent disease malaria.

Our team (Medicinal chemists, microbiologists, and molecular biologists) took an initiative process to develop a therapeutic regimen under laboratory conditions which will further subjected for developing as synthetic vaccines targeting cysteine protease (Facipain).

These synthetic vaccines ensures totipotency under human host environment without causing any undesirable effects, and can prophylaxis under a single optimum dose to the victims. 

My derived solution will be the best therapy till exists or developed by anyone. Because mostly pharmaceutical companies and other researchers usually neglects these malaria disease those are too vulnerable tin low income and poverty countries including villagers from US, Africans, subsaharans etc. 

Current scenario:

Malaria has proven to be the deadliest parasitic disease of humans. Recent update World Health Organization (WHO) estimated there were 219 million cases and 435,000 deaths from malaria in 2017. Plasmodium falciparum
is the most virulent human malaria parasite. WHO Global Malaria Programme (GMP) targets by 2030 to reduce malaria case incidence by at least 90%, reduce malaria mortality rates by at least 90%, eliminate malaria in at least 35 countries and prevent resurgence of malaria in all countries that are malaria-free  Malaria still has an overwhelming burden in the tropical and sub-tropical regions of the world, especially in the sub- Saharan Africa where pregnant women and infants mostly below age five are the most susceptible to parasitic disease. The treatment of malaria is becoming more challenging with increasing drug resistance of the malaria parasite. 

Based upon thorough literature exploration we came up with an unique macromolecular targets Cysteine Proteases( Falcipains) that can effectively inhibits the sporozoites at initial stage of malaria life cycle. The developed therapeutics ensures for hemoglobin digestion in the acidic food vacuole of Plasmodium providing free amino acids for parasite survival. 

We will take an initiative for developing under laboratory conditions keeping compatible with host environment where we will be developing a synthetic vaccines that can effectively cures to all malaria victims including maternal and newborns. 

In 1986, Manuel Elkin Patarroya innovated SPf66, the first version of a synthetic vaccine for treating malaria. Due to tremendous prevalence, variations of regions, vaccines couldn't be effectively targets all types of plasmodiums and unable to prevent barrier between transmission of sporozoites from suffering pregnant women to neonates. 

Many other synthetic vaccines, drug-antibodies conjugates discovered by scientists still having few research gaps to tackle it out during clinical trials.

Peptide based synthetic vaccines will prove to tackle all kind of research questions and gaps which will be lifesaver and one dose instant relieving remedy ever made by a researcher is our main motto for this SOLVE challenge.

Our novel slution will be based upon synthetic aspects for breaching burden of plasmodium diseases across global. The proposed solution will reach to the following targets:

1. To low income, poverty, undeveloped regions
2. Victims mostly pregnant women and infants those are vulnarable to this plasmidum disease in sub-saharans, Africans etc.
3. Many maternal and new borne neonates those are susceptible in outskirts of Northern Americas and villagers nearby.
4. Plasmodium victims in worldwide

Due to presence of research gaps, neglecting these deadliest diseases. 

At current mostly researcher focuses on high prioritize diseases as enlisted in WHO. So very rare are targeting to this disease.

Development of synthetic vaccines make an innovative design concept that make our team superior and unique from existance.

We will be subjecting this therapy into animal studies, human studies and subjects where maternal will be considered to showcase a best evidence solution. All experimental works will be based upon ethical considerations.

At present we have three members in our team. We will be collaborating with MMV, availing NIH grants, if our solution will enlightens under SOLVE panelists, we will encourage to collaborate with MIT experts. 

We will be trying to remove pebbles from the shoes where it can gradually deceased the maternal and early infants births problems including neural birth defects, maternal based genetically disorders, vulnerable pregnant women having Malaria and undergoing sufferings from COVID-19 with in five years.

External research supports and grants.

Would like to collaborate with MIT experts because MIT serves as the hotspots for resolving issues with innovative ideas. I would like to take initiative for open up the current solution in front of expert panelists where I can able to disclose what had done?, what to be done? and how to be done? 

SOLVE can enlighten me to breach this research barrier.

Our resolving environment is the research laboratory under Academic institution (University of Petroleum & Energy Studies), also we will be collaborating with other professionals from other countries (US) under the same research fields.

At present in our team myself and my backbone supporter Dr Neeraj Mahindroo (supervisor) works together. As we both belongs from School of Health Sciences our other faculties, and few from overseas plays a crucial role for supporting us.

At present we have full time experts : 3

We will be collaborating from other countries experts

We all belongs from pharmaceutical sciences research areas for providing best possibilities and challenges to other relevant research fields like Molecular Genetics, Molecular Biology, Biotechnology, AI based healthcare models, and etc. 

Our team employs all above mentioned research field together where as a team we work together to provide all ways of solution with proven evidences through ethical acknowledgments trials.

At present we all are in academicians. We have collaborations with other research labs for screening, biological assessments, clinical studies from other countries. Few collaborators are from Taiwan, US, eminence universities from our country.

MIT SOLVE proven to be the remarkable platform where young minds, experts, emeritus, youths, etc. comes up with an initiative and innovative ideologies based upon specific issues those are ongoing since past several years or decades. There own experiences surviving all day and circumventing for tackling problems let them challenges and enthusiastic to resolve or solve so none of the citizens would face such kind of hurdles.

Based on this aspect, I also came up with my own novelty solution that will arises intellectual thinking for escaping velocity and resolving the current strategies that can mitigate and prophylaxis present burden. 

I cordially appeal and would like to take an oath that MIT SOLVE intrigues for allowing me to stand-up and provides an lifetime opportunity for resolving my stated problem. Through SOLVE I can also be grateful and able to make collaborations with MIT experts, and others where we can able to come up with a fascinating  solution together. 

At present I serves as Doctoral Research Fellow at UPES, India. My supervisor (Dr Neeraj Mahindroo) and collaborators from MIT teams (faculties, experts, emeritus, etc.) would like to take up this initiative to progress ahead together.